Core Regenerative
Polynucleotides (PN)
Long-chain DNA polymers
Hydration and regeneration in one molecule
Origin: Salmon testes
How It Works
Polynucleotides are higher-molecular-weight DNA polymers than PDRN — longer chains that provide both a direct regenerative stimulus and a biopolymer scaffold within the dermis. They activate fibroblasts via adenosine receptor pathways (primarily A2A and A1) to produce new collagen type I, type III, and elastin fibres. Their hydrophilic nature also directly attracts and retains water within the dermis, improving deep hydration through a mechanism complementary to — but distinct from — hyaluronic acid. Ultrasound imaging in clinical studies has shown measurable increases in dermal thickness following PN treatment.
Clinical Evidence
PN skin boosters are the fastest-growing category in aesthetic medicine. A 2021 prospective clinical study found that PN injections produced a significant increase in skin hydration (corneometry), with 82% of participants rating improvement at 8 weeks. A 2022 pilot study found a 23% increase in ultrasound-measured dermal thickness after 8 weeks of topical 1.5% PN application. A 2023 RCT showed a 19% reduction in transepidermal water loss in subjects using a PN-based topical formulation, indicating improved barrier function.
Polynucleotide Skin Booster for Facial Skin Quality
2021Significant increase in skin hydration; 82% of participants rated improvement at 8 weeks (n=60 prospective study).
Topical Polynucleotide and Dermal Collagen Density
202223% increase in ultrasound-measured dermal thickness and improved collagen density after 8 weeks daily application (n=28 pilot).
PN Complex and Skin Barrier in Atopic-Prone Skin
202319% reduction in transepidermal water loss; improved barrier integrity in compromised skin (n=45 RCT).
How to Use
Use PN serum morning and evening after cleansing and toning. The ingredient works cumulatively — expect visible changes in skin texture and plumpness after 4–6 weeks of consistent use. Layer under a ceramide-rich moisturiser to amplify barrier support. When used alongside injectable PN treatments, topical PN helps maintain and extend clinical results between sessions.
Best For
All skin types; particularly beneficial for dry, dehydrated, or aging skin; excellent pre- and post-procedure care alongside injectable PN boosters
Cautions
Excellent safety profile. As with PDRN, contraindicated in confirmed fish allergy. Suitable for sensitive skin.
Key Benefits
- Deep hydration
- Dermal thickening
- Barrier repair
- Elasticity
- Fibroblast activation
Pairs Well With
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