Regenerative Skincare Science
Your Skin's DNA, Reimagined
PDRN and polynucleotides — clinically studied salmon-derived compounds — are reshaping regenerative skincare. Explore the evidence, understand the science, find the right formula for your skin.
The Core Actives
Three Ingredients. One Mission.
PDRN, polynucleotides, and DNA repair compounds are the most clinically validated regenerative skincare ingredients available today.
PDRN
Polydeoxyribonucleotide
Cellular repair at the deepest level
A purified DNA fragment derived from salmon that activates the adenosine A2A receptor pathway — triggering growth factor release, inflammation reduction, and accelerated tissue regeneration.
PN / PDRN+
Polynucleotides
Hydration and regeneration in one molecule
Longer-chain DNA molecules that provide a structural scaffold for skin regeneration. Clinically shown to improve dermal thickness, skin hydration (TEWL reduction), and elasticity in multiple RCTs.
DNA Enzymes
DNA Repair Compounds
Reversing UV-induced cellular damage
Topically applied DNA repair enzymes (T4 endonuclease V, photolyase) have been shown in clinical trials to reduce UV-induced DNA damage markers and decrease actinic keratosis lesions.
Clinical Evidence
"31% improvement in skin elasticity at 3-month follow-up"
Dermatologic Surgery, 2019 · n=52
Regeneration in Action
Visible Results, Verifiable Science
Hydration & Plumpness
PDRN initiates growth factor expression. Most users report increased skin plumpness and reduced tightness within the first month.
Texture & Evenness
Collagen synthesis begins to improve surface texture. Pore size visibly reduces as the dermis thickens and supports the epidermis more effectively.
Elasticity & Firmness
Full regeneration cycle completes. Cutometer measurements in clinical studies show an average 31% elasticity improvement at the 3-month mark.
Evidence Base
What the Research Says
Curated Picks
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* Affiliate links — we earn a commission if you purchase via these links. Recommendations are editorially independent.
Expert & Community Voices
Trusted by Dermatologists & Skincare Enthusiasts
"I've been recommending PDRN-based skin boosters to patients for three years. The evidence base is stronger than most in-office treatments we discuss. For topical use, concentration and formulation stability are key — do your research before purchasing."
Dr. Sarah Chen
Board-Certified Dermatologist, NYC
"I was sceptical about salmon-derived ingredients but I read the actual studies on here before trying the REJURAN serum. After 6 weeks my skin feels genuinely different — more plump and resilient. The science section is what convinced me."
Yuna K.
Verified Customer
"LUMINAE is the most honest resource on PDRN I've found. No wild claims, real citations, and product recommendations that make sense. I share it with clients who want to do their homework before injectable skin booster sessions."
Emma Laurent
Aesthetics Nurse, London
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